Novel insulin analogs with enhanced zinc binding

Details Novel insulin analogs with enhanced zinc binding Novel insulin analogs with enhanced zinc binding

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) C12N 15/17 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2330183

The invention relates to insulin analogs exhibiting enhanced zinc binding capacity and to stable zinc complexes thereof having a retarded activity in comparison with human insulin. The invention further relates to a method for the production of said insulin analogs and to their use, particularly in pharmaceutical preparations for therapy of type I and type II diabetes mellitus.

L'invention concerne des analogues de l'insuline présentant un pouvoir de liaison accru avec le zinc. Elle concerne également des complexes zinc-analogues d'insuline stables qui présentent un profil d'activité retardé par rapport à l'insuline humaine. L'invention concerne en outre un procédé de production desdits analogues ainsi que l'utilisation de ces derniers notamment dans des préparations pharmaceutiques pour le traitement du diabète sucré de type I mais aussi de type II.

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