Novel insulin derivatives

Details Novel insulin derivatives Novel insulin derivatives

C - Chemistry, Metallurgy

07

K

C07K 14/62 (2006.01) A61K 38/28 (2006.01) A61P 5/50 (2006.01)

Patent

CA 2531988

The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the a-amino group of the N-terminal amino acid residue of the B chain or to the e-amino group of a Lys residue present in the B chain of the parent insulin, the side chain being of the general formula: -W-X-Y-Z wherein W, X, Y and Z are as defined in the disclosure.

La présente invention concerne des dérivés de l'insuline qui sont des insulines naturelles ou des analogues de celles-ci présentant une chaîne latérale rattachée soit au groupe aminé .alpha. du reste d'acide aminé N-terminal de la chaîne B, soit au groupe aminé .epsilon. d'un reste Lys se trouvant dans la chaîne B de l'insuline mère ; la chaîne latérale étant représentée par la formule générale: -W-X-Y-Z, dans laquelle W, X, Y et Z sont tels que définis dans la divulgation.

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