C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/62 (2006.01)
Patent
CA 2711752
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
L'invention concerne de nouveaux analogues d'insuline à profil temporel/d'action basal, caractérisés par une addition et/ou une substitution de radicaux aminoacide chargés négativement et positivement, et par une amidation du groupe carboxy C-terminal de la chaîne B, et de l'histidine en position 8 de la chaîne A de l'insuline. L'invention concerne également la fabrication et l'utilisation de ces analogues d'insuline.
Habermann Paul
Kurrle Roland
Mueller Guenter
Seipke Gerhard
Sommerfeld Mark
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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