Novel insulin/igf/relaxin family polypeptides and dnas thereof

Details Novel insulin/igf/relaxin family polypeptides and dnas thereof Novel insulin/igf/relaxin family polypeptides and dnas thereof

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 38/17 (2006.01) A61K 38/28 (2006.01) A61K 38/30 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) A61P 5/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 17/00 (2006.01) A61P 19/00 (2006.01) A61P 25/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01) C07K 14/575 (2006.01) C07K 14/64 (2006.01) C07K 14/65 (2006.01) C07K 16/26 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12P 21/02 (20

Patent

CA 2406855

(1) A polypeptide having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:7 (strand A); (2) a polypeptide having an amino acid sequence being identical or substantially identical with the amino acid sequence represented by SEQ ID NO:8 (strand B); (3) a polypeptide wherein the strand A and B are bonded to each other via a disulfide bond (double-stranded) or its salt; (4) DNAs encoding the same, etc. These polypeptides and DNAs encoding the same are usable in, for example, diagnosing, treating and preventing diseases (diabetics, etc.) caused by metabolic errors of energy sources such as carbohydrates (for example, sugar metabolism, lipid metabolism).

L'invention concerne (1) un polypeptide dont une séquence d'acides aminés est identique ou sensiblement identique à la séquence d'acides aminés représentée par SEQ ID NO: 7 (souche A) ; (2) un polypeptide dont une séquence d'acides aminés est identique ou sensiblement identique à la séquence d'acides aminés représentée par SEQ ID NO: 8 (souche B) ; (3) un polypeptide où les souches A et B sont liées l'une à l'autre via une liaison disulfure (double souche) ou son sel ; (4) des ADN codant lesdits polypeptides, etc.. Lesdits polypeptides et les ADN codants correspondants peuvent servir, par exemple, au diagnostic, au traitement ou à la prévention de maladies (diabète, etc.) causées par des perturbations du métabolisme de sources d'énergie telles que les hydrates de carbone (notamment, le métabolisme du sucre, le métabolisme des lipides).

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