Novel integrin ligand itgl-tsp

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2228743

ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retinopathy), restenosis, Alzheimer's disease and tissue remodeling, among others, and diagnostic assays for such conditions.

Sont décrits des polypeptides ITGL-TSP, des polynucléotides et des méthodes de production de tels polypeptides par des techniques recombinantes. Sont aussi décrites des méthodes dans lesquelles sont utilisés les polypeptides ITGL-TSP et les polynucléotides permettant d'établir des protocoles pour le traitement des maladies angiogéniques (cancer, métastases cancéreuses, maladies inflammatoires chroniques, polyarthrite rhumatoïde, athérosclérose, dégénérescence maculaire, rétinopathie diabétique), de la resténose, de la maladie d'Alzheimer et du remodelage tissulaire, parmi d'autres, et pour les analyses diagnostiques de tels états.

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