Novel integrin receptor antagonists

Details Novel integrin receptor antagonists Novel integrin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/55 (2006.01) A61P 43/00 (2006.01) C07D 213/73 (2006.01) C07D 221/00 (2006.01) C07D 223/00 (2006.01) C07D 223/20 (2006.01) C07D 233/00 (2006.01) C07D 243/38 (2006.01) C07D 333/00 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/06 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2379977

The invention relates to novel compounds of formula (I) which bind to integrin receptors, wherein G and L have the following meaning: L is a structural element of formula IL, wherein T represents a COOH group or a radical that can be hydrolyzed to obtain COOH and U- represents (XL)a-(CRL1RL2)b-, -CRL1=CRL2-, ethylene or =CRL1-, wherein a is 0 or 1; b is 0, 1 or 2; XL represents CRL3RL4, NRL5, oxygen or sulfur and G is a structural element of formula IG, wherein the insertion of structural element G can occur in both orientations and XO represents nitrogen or CRG1. The invention also relates to the production of said compounds and to their use as medicaments.

L'invention concerne de nouveaux composés qui se lient aux récepteurs intégrines, ainsi que leur production et leur utilisation comme médicaments.

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