C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 255/45 (2006.01) A61P 25/24 (2006.01) C07C 45/29 (2006.01) C07C 45/46 (2006.01) C07C 45/63 (2006.01) C07C 49/84 (2006.01) C07C 253/00 (2006.01) C07C 255/36 (2006.01) C07C 255/37 (2006.01) C07D 303/48 (2006.01)
Patent
CA 2381334
Processes for the preparation of Venlafaxine (IX) via the novel epoxy- nitrile intermediate (I), which when subjected to hydrogenation forms compound (X), and may subsequently be reduced to yield the desired product (IX). The epoxy-nitrile intermediate (I) itself may be synthesised via various alternative reaction strategies, from a range of starting materials. E.g. 4- methoxy-benzaldehyde (VI), upon treatment with cyclohexyl magnesium bromide yields compound (V). This in turn may be oxidised to yield compound (III), which forms compound (II) on treatment with an .alpha.-keto- halogenation agent. Cyanation of compound (II), then yields the desired epoxy nitrile intermediate (I), from which Venlafaxine (IX) may be synthesised.
Deoahar Mandar Manohar
Gharpure Milind Moreshwar
Patel Nishant Mahendra
Rathod Dhiraj Mohansinh
Rengaraju Srinivasan
Alembic Limited
Bereskin & Parr
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