Novel intermediate for the synthesis of prostaglandins

C - Chemistry – Metallurgy – 07 – F

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C07F 7/18 (2006.01) C07C 405/00 (2006.01) C07D 405/00 (2006.01)

Patent

CA 2362132

An enantiomerically enriched compound of formula (1), wherein Ar is phenyl optionally substituted with one or more groups selected from haloalkyl, alkyl and halide. This compound can be isolated in crystalline form, and used in the preparation of (+)-16-[3-trifluoromethyl)phenoxyl-17,18,19,20-tetranor PGF2.alpha., isopropyl ester.

La présente invention concerne un composé de formule (1) enrichi de manière énantiomérique dans laquelle Ar est un phényle éventuellement substitué par un ou plusieurs groupes choisis parmi hydroalkyle, alkyle, halogénure. Ledit composé peut être isolé en forme cristalline, et utilisé dans la préparation de l'ester de (+)-16-[3-trifluorométhyl)phénoxy]-17, 18, 19 20-tetranor isopropyle de la prostaglandine F2 alpha.

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