Novel iron chelator and inhibitor of iron-mediated oxidation

Details Novel iron chelator and inhibitor of iron-mediated oxidation Novel iron chelator and inhibitor of iron-mediated oxidation

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A01N 1/02 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01)

Patent

CA 2185661

Exochelins can be used to prevent damage to living tissue from the formation or presence of the (OH) radical. In particular, the invention is directed to the administration of exochelins to infarcted myocardium prior to or coincidental with reperfusion to prevent damage to myocardium from iron mediated free radical formation. Also presented is the chemical structure of exochelins and modified exochelins at well as other applications of these materials in the treatment and diagnosis of disease in mammals.

On peut utiliser des exochélines pour éviter des lésions de tissus vivants provoquées par la formation ou la présence de radicaux (.OH). En particulier, l'invention concerne l'administration d'exochélines à un myocarde infarci avant ou en même temps qu'une reperfusion pour empêcher les lésions du myocarde provoquées par la formation de radicaux libres induits par le fer. On décrit également la structure chimique des exochélines et d'exochélines modifiées, ainsi que d'autres applications de ces composés pour le traitement de maladies chez les mammifères et leur diagnostic.

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