C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4353 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/4709 (2006.01) A61K 31/4985 (2006.01) A61P 35/00 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2499332
Novel isothiazole and isoxazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-P signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
L'invention concerne de nouveaux composés d'isothiazole et d'isoxazole, y compris leurs dérivés, leurs intermédiaires de préparation, des compositions pharmaceutiques les contenant ainsi que leur utilisation médicinale. Les composés de la présente invention sont de puissants inhibiteurs de la voie de signalisation du facteur de croissance transformant ("TGF")-.beta.. Ils sont utiles dans le traitement de divers états pathologiques liés au TGF notamment, par exemple, le cancer et des maladies fibreuses.
Blumberg Laura Cook
Munchhof Michael John
Pfizer Products Inc.
Smart & Biggar
LandOfFree
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