Novel isoxazoline and isoxazole fibrinogen receptor antagonists

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 498/10 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) C07D 261/00 (2006.01) C07D 261/04 (2006.01) C07D 261/10 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2174838

This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex. to pharmaceutical compositions containing such compounds, processes for preparing such compounds and to methods of using these compounds, alone or in combination with other therapeutic agents for the inhibition of platelet aggregation, as thrombolytics and/or for the treatment of thromboembolic disorders.

L'invention se rapporte à de nouveaux isoxazoles et isoxazolines aptes à être utilisés comme antagonistes du complexe récepteur de fibrinogène/glycoprotéine plaquettaire IIb/IIIa, à des compositions pharmaceutiques contenant ces composés, à des procédés de préparation de ces derniers ainsi qu'à des procédés permettant de les utiliser, seuls ou en combinaison avec d'autres agents thérapeutiques, comme agents thrombolytiques pour inhiber l'agrégation plaquettaire, et/ou pour le traitement de troubles thromboemboliques.

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