Novel isoxazoline and isoxazole fibrinogen receptor antagonists

Details Novel isoxazoline and isoxazole fibrinogen receptor antagonists Novel isoxazoline and isoxazole fibrinogen receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 413/12 (2006.01) A61K 31/42 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 261/04 (2006.01) C07D 261/08 (2006.01) C07D 261/10 (2006.01) C07D 413/00 (2006.01) C07D 413/04 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 453/02 (2006.01) C07D 455/02 (2006.01) C07D 471/04 (2006.01) C07D 473/00 (2006.01) C07D 475/00 (2006.01) C07D 487/0

Patent

CA 2222147

This invention relates to novel isoxazolines and isoxazoles which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex or the vitronectin receptor, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

L'invention porte sur de nouvelles isoxazolines et isoxazoles servant d'antagonistes du complexe récepteur du fibrinogène des glycoprotéines IIb/IIIa plaquettaires, ou du récepteur de la vitronectine, sur des préparations pharmaceutiques contenant lesdits composés, sur leurs procédés de préparation, et sur leurs méthodes d'utilisation, seuls ou en association avec d'autres agents thérapeutiques, comme inhibiteurs de l'agrégation plaquettaire, comme thrombolytiques, et/ou pour le traitement d'affections de caractère thrombo-embolique.

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