Novel isoxazoline fibrinogen receptor antagonists

Details Novel isoxazoline fibrinogen receptor antagonists Novel isoxazoline fibrinogen receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 261/04 (2006.01) A61K 31/42 (2006.01) A61K 31/454 (2006.01) A61P 7/02 (2006.01) C07D 261/08 (2006.01) C07D 413/06 (2006.01) C07D 413/10 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/10 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2345210

This invention relates to novel isoxazolines and isoxazoles of formula (I) or a pharmaceutically acceptable salt or prodrug form thereof. The invention relates to novel isoxazolines which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

L'invention concerne de nouveaux isoxazolines et isoxazoles correspondant à la formule (I) ou un sel pharmaceutiquement acceptable ou une forme de promédicament de ces composés. L'invention a pour objet de nouveaux isoxazolines qui peuvent servir d'antagonistes du complexe récepteur de fibrinogène IIb/IIIa glycoprotéines plaquettaires, des compositions pharmaceutiques contenant ces composés, des procédés pour préparer ces composés, isolément ou en combinaison avec d'autres agents thérapeutiques, qui sont utilisés pour inhiber l'agrégation plaquettaire, comme thrombolytiques et/ou dans le traitement de troubles thrombolytiques.

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