C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/00 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) A61P 25/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2491803
The invention encompasses polypeptides and polynucleotides of three novel bipolar disorder-associated potassium channel polypeptides, KCNQ2-15bx, KCNQ2- 15by and KCNQ2-15bz. The invention further relates to the use of potassium channels comprising KCNQ2 subunits for screening for modulators thereof, the use of these modulators for treating mental disorders such as bipolar disorder, schizophrenia and depression, and drugs comprising these modulators. The invention also discloses biallelic markers located in the KCNQ2 gene and their use for diagnosing mental disorders.
L'invention concerne les polypeptides et les polynucléotides de trois polypeptides de canal potassique associé à des troubles bipolaires, KCNQ2-15bx, KCNQ2-15by et KCNQ2-15bz. Elle concerne aussi l'utilisation de canaux potassiques contenant des sous-unités KCNQ2, afin de cribler leurs modulateurs, l'utilisation de ces modulateurs afin de traiter des troubles mentaux, notamment le trouble bipolaire, la schizophrénie et la dépression, ainsi que des médicaments contenant ces modulateurs. Elle concerne enfin des marqueurs bialléliques localisés dans le gène KCNQ2 et leur utilisation dans le diagnostic de troubles mentaux.
Cavarec Laurent
Chumakov Ilya
Destenaves Benoit
Elias Isabelle
Gonthier Catherine
Kirby Eades Gale Baker
Serono Genetics Institute S.a.
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