Novel kinase inhibitors

Details Novel kinase inhibitors Novel kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4412 (2006.01) A61K 31/444 (2006.01) A61K 31/50 (2006.01) A61K 31/501 (2006.01) A61P 19/02 (2006.01) C07D 213/72 (2006.01) C07D 237/22 (2006.01) C07D 401/10 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2701275

Pyridine and pyrimidine compounds according to formula (I) wherein R1, R2, R3, R4, R5, X~ and A are as described herein which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of formula (I) and at least one carrier, diluent or excipient.

L'invention concerne des composés de pyridine et de pyrimidine selon la formule (I), dans laquelle R1, R2, R3, R4, R5, X1 et A sont tels que décrits dans le présent document, qui inhibent Btk. Les composés décrits dans le présent document sont utiles pour moduler l'activité de Btk et pour traiter les maladies associées avec une activité excessive de Btk. Les composés sont également utiles pour traiter des maladies inflammatoires et auto-immunes associées avec une prolifération aberrante des cellules B, telles que l'arthrite rhumatoïde. L'invention concerne également des compositions qui contiennent des composés de formule I et au moins un véhicule, diluant ou excipient.

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