Novel lactam metalloprotease inhibitors

Details Novel lactam metalloprotease inhibitors Novel lactam metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/27 (2006.01) A61K 31/40 (2006.01) C07D 205/08 (2006.01) C07D 207/26 (2006.01) C07D 209/96 (2006.01) C07D 211/76 (2006.01) C07D 233/32 (2006.01) C07D 233/78 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 471/04 (2006.01) C07D 487/10 (2006.01)

Patent

CA 2305679

The present application describes novel lactams and derivatives thereof of formula (I), or pharmaceutically acceptable salt forms thereof, wherein ring B is a 4-8 membered cyclic amide containing from 0-3 additional heteroatoms selected from N, O, and S, which are useful as metalloprotease inhibitors.

L'invention concerne des lactames et des dérivés de lactame représentés par la formule (I), ou leurs sels pharmaceutiquement acceptables. Dans ladite formule, l'anneau B est une amide cyclique comportant entre 4 et 8 éléments, qui renferme de 0 à 3 hétéroatomes additionnels choisis parmi N, O et S. Les produits considérés sont utiles comme inhibiteurs de métalloprotéase.

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