C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/315 (2006.01) A61K 38/16 (2006.01) C07H 21/04 (2006.01) C12N 1/21 (2006.01) C12N 15/52 (2006.01) C12N 15/63 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2268744
Certain bacteria indigenus to humans produce antimicrobial substances called bacteriocins which inhibit other bacteria, including members of their own species. Mutacins are a class of antibiotic substances made by Streptococcus mutans. Disclosed is the purification and biochemical characterization of a novel lanthionine-containing mutacin peptide from S. mutans. The purified peptide is pH- and temperature-stable and its amino acid composition indicates the presence of lanthionine and .beta.-methyllanthionine. Also provided are methods of making and using the purified polypeptide.
Certaines bactéries indigènes chez l'homme produisent des substances antimicrobiennes appelées bactériocines, qui inhibent d'autres bactéries, dont des membres de leur propre espèce. Les mutacines sont une classe de substances antibiotiques fabriquées par Streptococcus mutans. L'invention a pour objet la purification et la caractérisation biochimique d'un nouveau peptide de mutacine contenant de la lanthionine, qui est extrait de S. mutans. Le peptide purifié a un pH et une température stables et sa composition en aminoacides indique la présence de lanthionine et de beta -méthyllanthionine. L'invention concerne également des procédés de fabrication et d'utilisation du polypeptide purifié.
Caufield Page W.
Novak Jan
Smart & Biggar
The Uab Research Foundation
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