Novel leader peptides for enhancing secretion of recombinant...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/62 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/32 (2006.01) C12N 1/21 (2006.01)

Patent

CA 2412374

Novel synthetic leader peptides have been identified. The leader peptides have use in a method of enhancing the secretion of a recombinant polypeptide produced in a host cell. Polynucleotides encoding the novel leader peptides and a method of designing the polynucleotides are described.

La présente invention concerne l'identification de nouvelles peptides synthétiques de tête. On utilise ces peptides de tête dans une méthode d'augmentation de la sécrétion d'un polypeptide recombiné produit dans une cellule hôte. Par ailleurs, cette invention concerne des polynucléotides qui codent ces nouvelles peptides de tête et un procédé de mise au point de ces polynucléotides.

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