C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/48 (2006.01) A61K 39/09 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/52 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2215929
lep polypeptides and DNA (RNA) encoding such lep and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such lep for the treatment of infection, particularly bacterial infections. Antagonists against such lep and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of lep nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding leader peptidase and for detecting the polypeptide in a host.
Polypeptides lep et ADN (ARN) codant pour ces lep, méthode pour obtenir ces polypeptides au moyen des techniques de l'ADN recombinant. Sont également décrits : des méthodes pour utiliser ces lep dans le traitement des infections, notamment les infections bactériennes; des antagonistes de ces lep et leur utilisation dans le traitement des infections, notamment les infections bactériennes; des essais diagnostiques pour détecter les maladies liées à la présence de séquences d'acide nucléique lep et des polypeptides dans un hôte; des essais diagnostiques pour la détection des polynucléotides codant une peptidase signal et la détection des polypeptides dans un hôte.
Gowling Lafleur Henderson Llp
Smithkline Beecham Corporation
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