A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 405/14 (2006.01) C07D 473/34 (2006.01) G01N 33/53 (2006.01) G01N 33/531 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2398435
A process is disclosed for modifying a parent ligand by attaching to the parent ligand a conjugation agent that is reactive with a moiety of a target receptor to which the parent ligand binds such that a covalent bond is formable between the conjugation agent and the receptor moiety. Also disclosed are compositions, probes and methods of detecting and/or quantifying receptors using the modified ligands of the invention.
L'invention concerne un processus permettant de modifier un ligand naturel ou non par fixation à ce dernier d'un agent de conjugaison qui est réactif avec un fragment d'un récepteur cible auquel le ligand naturel ou non se lie de manière telle qu'une liaison covalente peut être formée entre l'agent de conjugaison et le fragment du récepteur. L'invention concerne également des compositions, des sondes et des procédés permettant de détecter et/ou de quantifier des récepteurs au moyen des ligands modifiés selon l'invention.
Borden Ladner Gervais Llp
National University Of Singapore
LandOfFree
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