Novel ligands of the neuropeptide receptor hfgan72

Details Novel ligands of the neuropeptide receptor hfgan72 Novel ligands of the neuropeptide receptor hfgan72

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) C07K 16/26 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2218452

Polypeptides of HFGAN72 receptor ligands and polynucleotides encoding the polypeptides are provided. Methods of using these polypeptides to diagnose diseases relating to the under- or over-expression of HFGAN72 receptor ligands are also provided. In addition, methods of identifying agonists or antagonists of the interaction of HFGAN72 receptor ligands with the HFGAN72 receptor are provided. Methods of treatment byadministering the identified agonists or antagonists to patients in need thereof are further disclosed.

On dévoile des polypeptides qui sont des ligands du récepteur HFGAN72 et des polynucléotides codant ces polypeptides; des méthodes d'utilisation de ces polypeptides pour le diagnostic de maladies liées à une sous-expression ou à une surexpression des ligands du récepteur HFGAN72; des méthodes pour l'identification d'agonistes ou d'antagonistes de l'interaction des ligands du récepteur HFGAN72 avec le récepteur HFGAN72 ainsi que des méthodes de traitement par administration des agonistes ou antagonistes identifiés aux patients qui en ont besoin.

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