Novel lipase

Details Novel lipase Novel lipase

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) A61K 38/43 (2006.01) C07K 16/40 (2006.01) C12N 15/55 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2416191

A novel phospholipase A1 (PLA1) having a substrate specificity to phosphatidic acid (PA); a peptide or a polypeptide originating in the above novel PLA1; a polynucleotide encoding the peptide or polypeptide originating in the novel PLA1; a process for producing the peptide or polypeptide originating in the novel PLA1; an antibody against the peptide or polypeptide originating in the novel PLA1; a method of identifying an inhibitor, an antagonist or an activator of the novel PLA1 by using the same; compounds identified by the above method; and medicinal compositions and diagnostic methods by using the same.

La présente invention concerne une nouvelle phospholipase (PLA¿1?) présentant une spécificité de substrat par rapport à l'acide phosphatidique (PA); un peptide ou un polypeptide issu de cette nouvelle phospholipase; un polynucléotide codant pour le peptide ou le polypeptide issu de la nouvelle phospholipase; un procédé permettant de produire ce peptide ou ce polypeptide; un anticorps contre le peptide ou le polypeptide susmentionné; un procédé permettant d'identifier un inhibiteur, un antagoniste ou un activateur de la nouvelle phospholipase à l'aide dudit peptide ou du polypeptide issu de la nouvelle phospholipase; des composés identifiés grâce au procédé susmentionné; ainsi que des compositions médicamenteuses et des méthodes diagnostiques utilisant ces compositions.

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