Novel local anesthetic compounds and uses

Details Novel local anesthetic compounds and uses Novel local anesthetic compounds and uses

C - Chemistry, Metallurgy

07

C

C07C 233/04 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) A61K 31/445 (2006.01) C07C 237/04 (2006.01) C07C 237/34 (2006.01) C07D 211/60 (2006.01) C07D 273/00 (2006.01) C07D 273/08 (2006.01)

Patent

CA 2315946

Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na+ channel to modulate the biological processes/functions thereof.

L'invention concerne de nouveaux composés, compositions pharmaceutiques et méthodes afférentes de production d'un anesthésique local à longue durée. Les composés de la présente invention sont des composés à liaisons multiples comprenant 2 à 10 ligands fixés de manière covalente à une ou des séquences de liaison, chaque ligand étant capable de se lier à un site de liaison de ligand dans un canal Na?+¿ dépendant du potentiel pour moduler les procédés/fonctions biologiques de ce dernier.

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