Novel lupane derivatives, their preparation and...

Details Novel lupane derivatives, their preparation and... Novel lupane derivatives, their preparation and...

C - Chemistry, Metallurgy

07

J

C07J 63/00 (2006.01) A61K 31/56 (2006.01) C07D 257/04 (2006.01) C07D 257/06 (2006.01)

Patent

CA 2162703

Lupane derivatives of general formula (I) in which R is: (II), wherein X is a bond or an optionally substituted carbamoyl or aminocarbonyl, Y is a bond or phenylene, R DEG and R DEG DEG , which are the same or different, are H or methyl and n is 6 to 12, m is 0 to 3 and p is 0 to 2, with 6 </= m+n+p </= 14, and R1 is methyl, hydroxymethyl, -CH2OR' or -CH2SR' (R' is alkyl or hydroxyalkyl), the alkyl radicals (1 to 4C) are straight or branched. The invention also concerns the salts of said derivatives and their preparation. The products according to the invention are especially useful in the treatment of AIDS and in infections induced by the herpes family of viruses.

Dérivés du lupane de formule générale (I) dans laquelle R est: (II), dans laquelle X est une liaison, carbamoyole ou aminocarbonyle éventuellement substitués, Y est une liaison ou phénylène, R° et R°° identiques ou différents sont H ou méthyle et, n est 6 à 12, m est 0 à 3 et p est 0 à 2, avec: 6 m+n+p 14, et R1 est méthyle, hydroxyméthyl,-CH2OR' ou -CH2SR' (R' étant alcoyle ou hydroxyalcoyle), les radicaux alcoyle (1 à 4C) etant droits ou ramifiés, ainsi que leurs sels et leur préparation. Les produits selon 1' invention sont intéressants dans les domaine du SID A et dans less affections médiées par les virus de la famille des herpès.

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