C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/60 (2006.01) C12N 1/20 (2006.01) C12N 9/88 (2006.01) C12P 13/08 (2006.01)
Patent
CA 2207271
L-lysine is produced efficiently by cultivating, in a liquid medium, a microorganism belonging to the genus Escherichia with decreased or disappeared lysine decarboxylase activity relevant to decomposition of L-lysine, for example, a bacterium belonging to the genus Escherichia with restrained expression of a novel gene coding for lysine decarboxylase and/or a known gene cadA to allow L-lysine to be produced and accumulated in a culture liquid, and collecting it.
La L-lysine est produite efficacement par culture dans un milieu liquide d'un microorganisme appartenant au genre Escherichia, dans lequel l'activité de la lysine-décarboxylase participant à la décomposition de la L-lysine a été réduite ou supprimée, par exemple une bactérie du genre Escherichia ayant une expression limitée d'un nouveau gène codant la lysine-décarboxylase et/ou d'un gène cadA connu pour permettre la production et l'accumulation de la L-lysine dans le liquide de culture, puis sa collecte.
Kikuchi Yoshimi
Kojima Hiroyuki
Suzuki Tomoko
Ajinomoto Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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