Novel macrocyclic compounds as metalloprotease inhibitors

Details Novel macrocyclic compounds as metalloprotease inhibitors Novel macrocyclic compounds as metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 267/00 (2006.01) A61K 31/395 (2006.01) A61K 31/675 (2006.01) C07D 245/02 (2006.01) C07D 255/02 (2006.01) C07D 273/02 (2006.01) C07D 273/08 (2006.01) C07D 291/02 (2006.01) C07D 401/00 (2006.01) C07D 401/12 (2006.01) C07D 403/00 (2006.01) C07D 403/12 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 411/00 (2006.01) C07D 413/00 (2006.01) C07D 413/12 (2006.01) C07D 417/00 (2006.01) C07D 417/12 (2006.01) C07D 419/00 (2006.01) C07D 419/12 (2006.01) C07D 453/02 (2006.01) C07D 471/04 (2006.01) C07D 4

Patent

CA 2237524

This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.

L'invention concerne des molécules macrocycliques qui inhibent les métalloprotéinases, y compris l'agrécanase, et la production du facteur de nécrose tumorale (TNF). En particulier, les composés en question inhibent les métalloprotéinases intervenant dans la dégradation des tissus, d'une part, et la libération du TNF, d'autre part. On décrit par ailleurs des compositions pharmaceutiques renfermant ces composés et un certain nombre de procédés relatifs à l'utilisation de ces composés pour le traitement des maladies inflammatoires.

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