C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 273/02 (2006.01) A61K 31/395 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01) C12Q 1/25 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2287923
This invention relates to macrocyclic molecules of formula (I) which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases. A novel enzymatic assay was developed to detect potential inhibitors of aggrecanase. The assay uses active aggrecanase accumulated in media from stimulated bovine nasal cartilage (BNC) or related cartilage sources and purified cartilage aggrecan monomer or a fragment thereof as a substrate.
La présente invention concerne des molécules macrocycliques inhibant des métalloprotéases, y compris une aggrécanase, et la production d'un facteur de nécrose des tumeurs (TNF). En particulier, les composés sont des inhibiteurs de métalloprotéases intervenant dans la dégradation de tissus et des inhibiteurs de libération de facteur de nécrose des tumeurs. La présente invention concerne également des compositions pharmaceutiques comprenant de tels composés, ainsi que des méthodes d'utilisation de ces composés dans le traitement d'affections inflammatoires.
Arner Elizabeth
Cherney Robert J.
Decicco Carl P.
Degrado William F.
Duan Jingwu
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
LandOfFree
Novel macrocyclic compounds as metalloprotease inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel macrocyclic compounds as metalloprotease inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel macrocyclic compounds as metalloprotease inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2025735