Novel macrocyclic inhibitors of hepatitis c virus replication

Details Novel macrocyclic inhibitors of hepatitis c virus replication Novel macrocyclic inhibitors of hepatitis c virus replication

C - Chemistry, Metallurgy

07

K

C07K 5/12 (2006.01) A61K 38/00 (2006.01) A61P 31/14 (2006.01) C07C 231/02 (2006.01) C07C 269/00 (2006.01) C07D 207/16 (2006.01) C07D 209/44 (2006.01)

Patent

CA 2615666

The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

La présente invention concerne des composés de la formule générale (I) à la formule générale (VIII), ainsi que des compositions, comprenant des compositions pharmaceutiques, comprenant un composé sujet. La présente invention concerne également des procédés de traitement, comprenant des procédés de traitement de l~infection par le virus de l~hépatite C et des procédés de traitement de la fibrose hépatique, les procédés impliquant généralement l~administration à un individu nécessitant celle-ci une quantité efficace d~un composé ou d~une composition sujet.

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