Novel macrocyclic inhibitors of hepatitis c virus replication

Details Novel macrocyclic inhibitors of hepatitis c virus replication Novel macrocyclic inhibitors of hepatitis c virus replication

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/407 (2006.01) A61P 31/12 (2006.01) C08H 1/00 (2006.01)

Patent

CA 2686138

The embodiments provide macrocyclic compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.

Les modes de réalisation de la présente invention concernent des composés de formule générale (I), ainsi que des compositions, y compris des compositions pharmaceutiques, comprenant un composé sujet de l'invention. Les modes de réalisation concernent en outre des procédés de traitement, y compris des procédés de traitement d'une infection par le virus de l'hépatite C et des procédés de traitement d'une fibrose hépatique, lesdits procédés comprenant généralement l'administration à un individu qui en a besoin d'une quantité efficace d'une composition ou d'un composé sujet de l'invention.

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