Novel macrocyclic lactones and a productive strain thereof

C - Chemistry – Metallurgy – 12 – P

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C12P 17/18 (2006.01) A01N 43/90 (2006.01) A61K 31/445 (2006.01) C07D 498/18 (2006.01) C07H 19/01 (2006.01) C12N 1/20 (2006.01) C12P 19/26 (2006.01) A61K 31/71 (1990.01)

Patent

CA 2128529

2128529 9316189 PCTABS00025 This invention provides the novel culture, Streptomyces hygroscopicus) FERM BP-3688 and the macrocyclic lactones which were produced by the culture Streptomyces hygroscopicus (FERM BP-3688), Actinoplanes sp. (FERM BP-3832) or Streptomyces toyocaensis subsp.humicola) (ATCC 39471) and an immunosuppressive agent, an antimycotic agent and an antitumor agent which comprises the said macrocyclic lactones. The macrocyclic lactones have formula (I) wherein R1 is oxygen, two hydrogens or one hydrogen and one hydroxy; R2, R3 and R5 are each independently hydrogen, hydroxy or methoxy; and R4 is hydroxy or hydrogen; provided that when R1 is oxygen, R4 is hydroxy and R2 and R5 are methoxy, R3 is neither hydrogen nor methoxy.

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