C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/08 (2006.01) A61K 31/70 (2006.01)
Patent
CA 2316919
The invention relates to novel erythromycin analogs and azalides, particularly ones with novel C-13 substituents, and to pharmaceutically acceptable salts thereof. The compounds of this invention are antibacterial agents that may be used to treat various bacterial and protozoa infections. The invention also relates to pharmaceutical compositions containing such compounds and to methods of treating bacterial protozoa infections by administering such compounds. The invention also relates to methods of preparing such compounds and to intermediates useful in such preparation.
L'invention concerne de nouveaux analogues et azalides d'érythromycine, en particulier ceux avec de nouveaux substituants C-13, ainsi que les sels pharmaceutiquement acceptables de ces dérivés. Les composés de cette invention constituent des agents antibactériens pouvant être utilisés pour traiter diverses infections bactériennes ou des protozooses. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, ainsi que des méthodes permettant de traiter des infections bactériennes ou des protozooses par administration de ces composés. L'invention concerne enfin des méthodes de préparation de ces composés et des produits intermédiaires utiles à cette préparation.
Dirlam John Philip
Mcarthur Hamish Alastair Irvine
Pfizer Products Inc.
Smart & Biggar
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