C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01)
Patent
CA 2676797
The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof.
La présente invention concerne de nouveaux peptides MTD (Macromolecule Transduction Domain = domaine de transduction de macromolécule) qui facilite le passage d'une molécule biologiquement active au travers de la membrane de la cellule. L'invention concerne également des polynucléotides codant les peptides MTD, des procédés d'identification des peptides MTD, des procédés de production par génie génétique d'une molécule biologiquement active capable de perméabilité cellulaire par utilisation des peptides MTD, des procédés d'importation d'une molécule biologiquement active dans une cellule par utilisation des peptides MTD, et les utilisations correspondantes.
Do Thi Lan Phuong
Do Thi Thuy Nga
Duong Minh Tam
Jo Dae Woong
Kim Jin Sook
Do Thi Lan Phuong
Do Thi Thuy Nga
Duong Minh Tam
Gowling Lafleur Henderson Llp
Jo Dae Woong
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