C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/51 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/198 (2006.01) A61K 31/223 (2006.01) A61K 31/235 (2006.01) A61K 31/27 (2006.01) A61K 31/275 (2006.01) A61K 31/341 (2006.01) A61K 31/345 (2006.01) A61K 31/351 (2006.01) A61K 31/36 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4164 (2006.01) A61K 31/4166 (2006.01) A61K 31/4184 (2006.01) A61K 31/4192 (2006.01) A61K
Patent
CA 2690226
The present invention provides a novel compound having an agonist action at AT2 receptor and expected as a pharmaceutical product, and also provides a method of treating or preventing various diseases. The novel sulfonyl malonamide derivative, or a pharmacologically acceptable salt thereof or a solvate thereof of the present invention has therapeutic and/or preventive effect(s) on various diseases due to its agonist action at AT2 receptor, and is useful as a pharmaceutical agent for the treatment and/or prevention of diseases involving the renin-angiotensin-aldosterone system (RAAS).
L'invention concerne un nouveau composé qui présente un agonisme du récepteur AT2 et qui est susceptible d'être utilisé comme un produit pharmaceutique et de fournir un procédé thérapeutique ou préventif pour diverses maladies. L'invention concerne également un nouveau dérivé sulfamide d'acide malonique, un sel pharmaceutiquement acceptable de celui-ci et un solvate de celui-ci, qui présentent un effet thérapeutique et/ou préventif sur diverses maladies du fait de l'agonisme du récepteur AT2 et qui sont utiles en tant que produit pharmaceutique pour traiter et/ou prévenir des maladies associées avec le système rénine-angiotensine-aldostérone (SRAA).
Kawasumi Hisashi
Numata Atsushi
Sakashita Hiroshi
Tahara Saori
Yoshida Tomohiro
Fetherstonhaugh & Co.
Mitsubishi Tanabe Pharma Corporation
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