C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2651051
This application provides the use of novel fetal markers for prenatal diagnosis and monitoring of certain pregnancy-related conditions. More specifically, the invention resides in the discovery that certain CpG islands located on fetal chromosome 21 demonstrate a methylation profile that is distinct from that of the corresponding CpG islands located on maternal chromosome 21. This application also provides kits for diagnosing or monitoring of the relevant conditions.
La présente invention concerne de nouveaux marqueurs fAEtaux pour le diagnostic et la surveillance prénataux de certaines affections en rapport avec la grossesse. Plus spécifiquement, l'invention concerne la découverte de ce que certains îlôts CpG localisés sur le chromosome 21 fAEtal démontrent un profil de méthylation distinct de celui des îlôts CpG correspondants localisés sur le chromosome 21 maternel. La présente invention concerne aussi des trousses pour le diagnostic ou la surveillance des affections pertinentes.
Chim Stephen Siu Chung
Chiu Rossa Wai Kwun
Ding Chunming
Jin Shengnan
Lee Tracy Yuen Han
Fetherstonhaugh & Co.
The Chinese University Of Hong Kong
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