Novel matrix metalloproteinase inhibitors and down-regulators

Details Novel matrix metalloproteinase inhibitors and down-regulators Novel matrix metalloproteinase inhibitors and down-regulators

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2323239

The present invention relates to novel matrix metalloproteinase (MMP) inhibitors and down-regulators, to a process for the preparation of these inhibitors, to pharmaceutical compositions comprising these inhibitors/down-regulators, to the use of the novel MMP inhibitors for the manufacture of pharmaceutical and research preparations, to a method for inhibiting and down-regulating MMP-dependent conditions either in vivo or in vitro, to a method for inhibiting formation, synthesis, expression activations, and/or functions as well actions of matrix metalloproteinases, and to the use of the novel MMP inhibitors and down- regulators in biochemical isolation and purification procedures of matrix metalloproteinases.

La présente invention concerne de nouveaux inhibiteurs et régulateurs négatifs de métalloprotéinases matricielles (MMP), un procédé de préparation de ces inhibiteurs, des compositions pharmaceutiques comprenant ces inhibiteurs/régulateurs négatifs, l'utilisation de ces nouveaux inhibiteurs de MMP pour la production de préparations pharmaceutiques et de recherche, une méthode d'inhibition et de régulation négative d'états dépendants de MMP in vivo ou in vitro, et une méthode pour inhiber la formation, la synthèse, des activations d'expression, et/ou des fonctions, ainsi que des actions des métalloprotéinases matricielles. L'invention concerne également l'utilisation de ces nouveaux inhibiteurs et régulateurs négatifs de MMP dans des procédures biochimiques d'isolement et de purification de métalloprotéinases matricielles.

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