Novel medical uses of compounds showing cb1-antagonistic...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01)

Patent

CA 2543338

The present invention relates to a novel medical use of compounds with CB1- ~receptor activity selected from the group of 4,5-dihydro-1H-pyrazole derivatives, 1H-lmidazole derivatives, thiazole derivatives and/or 1H-1,2,4- triazole-3-~carboxamide derivatives, as each defined in the specification, or of a prodrug thereof, a tautomer thereof or a salt thereof, in the manufacture of medicaments for the treatment and/or prophylaxis of CB1, receptor related diseases in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile, as well as in adolescent, patients. Furthermore, the invention pertains to the use of said compounds with CB1- receptor activity in combination with lipase inhibitors. Said compounds are particularly suitable in combination with lipase inhibitors in the manufacture of medicaments for the treatment and/or prophylaxis of obesity in adolescent or in juvenile patients and/or for the treatment and/or prophylaxis of drug induced obesity in juvenile as well as in adolescent patients. Preferred lipase inhibitors are orlistat, panclicins, ATL-962 and/or lipstatin.

La présente invention concerne une nouvelle utilisation médicale de composés présentant une activité de récepteur de CB¿1?, choisis dans le groupe des dérivés 4,5-dihydro-1H-pyrazole, des dérivés 1H-lmidazole, des dérivés thiazole, et/ou des dérivés 1H-1,2,4-triazole-3-carboxamide, tels que définis dans les spécifications, ou de certains de leurs promédicaments, tautomères ou sels. Les utilisations considérées concerne la fabrication de médicaments destinés au traitement et/ou à la prophylaxie d'affections en relation avec le récepteur du CB¿1? chez l'enfant, et/ou pour le traitement et/ou la prophylaxie de l'obésité médicamenteuse chez l'enfant ou l'adolescent. En outre, l'invention concerne l'utilisation de tels composés à activité de récepteur du CB¿1? en association avec des inhibiteurs des lipases. Ces composés conviennent particulièrement, en association avec des inhibiteurs des lipases, à la fabrication de médicaments destinés au traitement et/ou à la prophylaxie de l'obésité de l'adolescent ou de l'enfant, et/ou au traitement et/ou à la prophylaxie de l'obésité médicamenteuse de l'enfant et de l'adolescent. Les inhibiteurs de lipases préférés sont l'orlistat, les panclicines, l'ATL-962 et/ou la lipstatine.

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