C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61P 25/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2348479
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR- 2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing hVR-1, hVR- 2, and rVR-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an hVR- 1, hVR-2, and rVR-2 gene has been introduced or disrupted. The invention still further provides isolated hVR-1, hVR-2, and rVR-2 proteins, fusion proteins, antigenic peptides and anti-hVR-1, anti-hVR-2, and anti-rVR-2 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
L'invention concerne des nouvelles molécules d'acides nucléiques isolées, dénommées hVR-1, hVR-2 et rVR-2 et codant pour des nouveaux éléments de la famille réceptrice de capsicine/vanilloïde. L'invention concerne également de molécules d'acides nucléiques antisens, des vecteurs d'expression recombinés contenant les molécules d'acides nucléiques hVR-1, hVR-2 ou rVR-2, des cellules hôtes dans lesquelles on a introduit les vecteurs d'expression, ainsi que des animaux transgéniques, non humains, dans lesquels on a introduit ou dissocié le gène hVR-1, hVR-2 ou rVR-2. L'invention concerne encore des protéines isolées hVR-1, hVR-2, et rVR-2, des protéines de fusion, des peptides antigéniques et des anticorps dirigés contre hVR-1, hVR-2 et rVR-2, de même que des méthodes de diagnostic mettant en oeuvre les compositions de l'invention.
Borden Ladner Gervais Llp
Millennium Pharmaceuticals Inc.
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