Novel membrane or matrix for controlling drug permeation

Details Novel membrane or matrix for controlling drug permeation Novel membrane or matrix for controlling drug permeation

C - Chemistry, Metallurgy

08

G

C08G 77/24 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2351091

The invention relates to a membrane or matrix, made of a siloxane-based elastomer, and intended for controlling the permeation of drugs, wherein said elastomer comprises 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units. The invention relates also to a method for the preparation of a siloxane-based elastomer comprising 3,3,3,-trifluoropropyl substituents, wherein said elastomer is intended for controlling the permeation of drugs. In the method either i) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional cross-linking agent are cross-linked in the presence of a catalyst, or ii) a 3,3,3,- trifluoropropyl-substituted polysiloxane component is cross-linked in the presence of a peroxide catalyst.

L'invention traite d'une membrane ou matrice faite d'élastomère à base de siloxane et destinée au contrôle de la pénétration de médicaments. Ledit élastomère comprend des groupes 3,3,3,-trifluoropropyle fixés à des atomes Si d'unités de siloxane. L'invention traite également d'un procédé de préparation d'un élastomère à base de siloxane comprenant des substituants 3,3,3,-trifluoropropyle. Ledit élastomère est conçu pour contrôler la pénétration de médicaments. Selon le procédé, soit i) un composant polysiloxane à fonction vinyle substitué en 3,3,3,-trifluoropropyle et un agent à effet réticulant à fonction hybride sont réticulés en présence d'un catalyseur, soit ii) un composant polysiloxane substitué en 3,3,3,-trifluoropropyle est réticulé en présence d'un catalyseur péroxyde.

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