A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/409 (2006.01) A61K 41/00 (2006.01) A61K 51/04 (2006.01) C07D 487/22 (2006.01) C07F 5/02 (2006.01)
Patent
CA 2449316
The present invention covers radiosensitizers containing as an active ingredient halogenated derivatives of boronated porphyrins containing multiple carborane cages which selectively accumulate in neoplastic tissue within the irradiation volume and thus can be used in cancer therapies including, but not limited to, boron neutron-capture therapy and photodynamic therapy. The present invention also covers methods for using these radiosensitizers in tumor imaging and cancer treatment.
La présente invention porte sur des radiosensibilisateurs contenant comme ingrédient actif des dérivés halogénés de porphyrines boronées contenant plusieurs cages de carborane qui s'accumulent sélectivement dans le tissu néoplasique dans le volume de radiation et qui peuvent être ainsi utilisées dans les traitements des cancers tels que la thérapie de capture des neutrons du bore et la thérapie photodynamique. Cette invention porte également sur des procédés d'utilisation de ces radiosensibilisateurs dans l'imagerie des tumeurs et le traitement du cancer.
Miura Michiko
Slatkin Daniel N.
Brookhaven Science Associates
Mbm Intellectual Property Law Llp
LandOfFree
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