C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 38/48 (2006.01) C07K 16/40 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 9/64 (2006.01) C12P 21/00 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2332533
Novel metalloproteases having thrombospondin domain(s) (MPTS proteins) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid compositions find use in a variety of applications, including diagnostic applications, therapeutic agent screening applications, as well as therapeutic applications for a variety of different conditions. Also provided are methods of treating disease conditions associated with aggrecanase activity, e.g. conditions characterized by the presence of aggrecan cleavage products, such as rheumatoid- and osteo-arthritis.
Heller Renu Anand
Klonowski Paul
Zuo Fengrong
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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