A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) A61P 9/00 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2379373
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or .beta.1 integrins are described. Such antagonists inhibit angiongenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or .beta.1 integrins are also described.
L'invention concerne des antagonistes destinés à modifier des interactions protéine-protéine impliquant certaines séquences d'acides aminés dans les intégrines MMP-9 et/ou .beta.1. Ces antagonistes inhibent l'angiogenèse, la croissance tumorale et des états pathologiques. Des antagonistes exemplaires sont des molécules polypeptidiques ou non polypeptidiques comprenant le nouvel anticorps Mab FM155 et le nouveau peptide synthétique FRIP-1. L'invention concerne des méthodes d'inhibition de l'angiogenèse et d'états pathologiques consistant à administrer ces antagonistes. Elle concerne également des méthodes d'identification d'antagonistes modifiant des interactions protéine-protéine impliquant certaines séquences d'acides aminés dans les intégrines MMP-9 et/ou .beta.1.
Brooks Peter C.
Hassanieh Loubna
Rodriguez Dorothy
Smart & Biggar
University Of Southern California
LandOfFree
Novel method and composition for inhibition of angiogenesis... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel method and composition for inhibition of angiogenesis..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel method and composition for inhibition of angiogenesis... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1656426