C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/18 (2006.01) C07K 14/245 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2365929
The present invention relates to a method for identifying an antagonist or inhibitor of the expression of a gene encoding a polypeptide essential for bacterial growth or survival as well as for an antagonist or inhibitor of said polypeptide. The invention further relates to a method for improved antagonists or inhibitors. The invention also provides an antagonist or inhibitor of the activity of said polypeptide. The invention is further related to a method for producing a therapeutic agent in a composition comprising said antagonist or inhibitor. Furthermore, the invention is related to the use of the polypeptide and the antagonist or inhibitor as well as to a method to identify a surrogate marker.
Cette invention concerne un procédé permettant d'identifier un antagoniste ou un inhibiteur d'expression d'un gène codant pour un polypeptide essentiel à la croissance bactérienne ainsi que pour un antagoniste ou un inhibiteur dudit polypeptide. Est également exposée une méthode propre à améliorer des antagonistes ou des inhibiteurs. L'invention concerne également un antagoniste ou un inhibiteur de l'activité dudit polypeptide, ainsi qu'un procédée permettant de produire un agent thérapeutique dans une composition renfermant ledit antagoniste ou inhibiteur. Cette invention concerne en outre l'utilisation du polypeptide et de l'antagoniste ou de l'inhibiteur ainsi qu'un procédé d'indentification d'un marqueur de substitution.
Grigoriev Andrei
Jacobi Alexander
Loferer Hannes
Borden Ladner Gervais Llp
Gpc Biotech Ag
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