Novel method for measuring insulin resistance

A - Human Necessities – 61 – K

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A61K 49/00 (2006.01) A61B 5/00 (2006.01) A61K 51/04 (2006.01) G01N 23/02 (2006.01) G01N 33/66 (2006.01) G01T 1/161 (2006.01) G06F 19/00 (2011.01)

Patent

CA 2731134

The present invention relates to the use of at least one glucose derivative, halogenated in the 6-position, for implementing a method for determining the insulin resistance in a mammal, in particular a human, by measuring - the variation in the amount (as a function of time) of the abovementioned derivative, in muscle cells, for a given period ?t, after administration of the abovementioned derivative, and - the variation in the amount (as a function of time) of the abovementioned derivative, in the abovementioned muscle cells, for a period substantially equal to the abovementioned period ?t, after administration of the abovementioned derivative, preceded by an administration of insulin.

La présente invention concerne l'utilisation d'au moins un dérivé du glucose, halogène en position 6, pour la mise en oeuvre d'un procédé de la détermination de l'insulino résistance chez un mammifère, notamment l'homme, par mesure - d'une part de la variation de la quantité (en fonction du temps) du susdit dérivé, dans des cellules musculaires, pendant une durée donnée .increment.t, après administration du susdit dérivé, et - d'autre part de la variation de quantité (en fonction du temps) du susdit dérivé, dans les susdites cellules musculaires, pendant une durée sensiblement égale à la susdite durée .increment.t, après administration du susdit dérivé, précédée d'une administration d'insuline.

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