Novel method for preparation of ammonium salts of esomeprazole

C - Chemistry – Metallurgy – 07 – D

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C07D 401/12 (2006.01) A61K 31/4439 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2653429

The present invention relates to a process for the preparation of quartenary ammoniumsalts of esomeprazole. Further, the present invention also relates to the use quartenary ammoniumsalts of esomeprazole for the treatment of gastrointestinal disorders, pharmaceutical compositions containing them as well as the quartenary ammoniumsalts of esomeprazole, as such.

La présente invention concerne un procédé pour préparer des sels d'ammonium quaternaires d'ésoméprazole. De plus, la présente invention concerne également l'utilisation de sels d'ammonium quaternaires d'ésoméprazole dans le traitement de troubles gastro-intestinaux, des compositions pharmaceutiques les contenant, ainsi que les sels d'ammonium quaternaires d'ésoméprazole en tant que tels.

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