C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/04 (2006.01)
Patent
CA 2700161
The invention relates to a novel method for preparing (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin, which can be used in therapeutics as anticancer agents. The invention includes a step comprising the condensation of a primary amine reactant, the amine functions of which are not protected, with 4ß-chloroacetamido-4'-epipodophyllotoxin in an aprotic polar organic solvent.
La présente invention décrit un nouveau procédé de préparation des composés (poly)aminoalkylaminoacétamide d'épipodophyllotoxine, utiles pour leurs applications en thérapeutique comme agents anticancéreux.. Ce procédé comprend une étape de condensation d'un réactif aminé primaire dont les fonctions aminé ne sont pas protégées avec le 4.beta.-chloroacétamido-4'-épipodophyllotoxine dans un solvant organique polaire aprotique.
Grousseaud Martial
Guminski Yves
Imbert Thierry
Goudreau Gage Dubuc
Pierre Fabre Medicament
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