Novel method of diagnosing and treating gliomas

Details Novel method of diagnosing and treating gliomas Novel method of diagnosing and treating gliomas

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07K 14/435 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2249351

The present invention relates generally to the fields of cell physiology, neurology and neuro-oncology. More specifically, the present invention relates to a novel method of diagnosing and treating gliomas and meningiomas. The present invention describes the expression of a chloride conductance with unique properties that selectively characterizes tumor-derived cells of glial origin. In the present invention, whole-cell patch-clamp techniques were used to characterize the biophysical and pharamacological properties of chloride channels in primary cultures and acutely isolated cells from biopsies of human astrocytomas and established cell lines.

La présente invention concerne en général le domaine de la physiologie cellulaire, la neurologie et la neuro-oncologie. La présente invention concerne plus spécifiquement une nouvelle méthode pour diagnostiquer et traiter des gliomes et méningiomes. La présente invention concerne l'expression de canaux à chlorure présentant des caractéristiques exceptionnelles de conductance permettant la caractérisation sélective de cellules dérivées de tumeurs, d'origine gliale. Dans la présente invention, des techniques patch clamp sur cellule entière ont été appliquées pour caractériser les propriétés biophysiques et pharmacologiques de canaux à chlorure dans des cultures primaires et des cellules isolées avec précision à partir de biopsies d'astrocytomes humains et de lignées cellulaires établies.

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