A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/519 (2006.01) A61K 31/365 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) A61P 39/00 (2006.01)
Patent
CA 2560843
A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons.
Un procédé de neuroprotection comprend l'administration d'un inhibiteur d'AMPK à un patient qui souffre (ou qui a souffert) d'une attaque, le composé étant un inhibiteur d'AMPK. Les traitements avec ces agents réduisent sensiblement l'étendue de l'infarctus et minimisent ainsi la perte de tissu cérébral et de neurones. De cette manière, la fonction peut être préservée après une attaque ou des lésions ischémiques au cerveau. De façon similaire, une perte neuronale peut être minimisée dans le cas de maladies dégénératives qui provoquent un compromis neuronal en perturbant l'utilisation de l'énergie et la disponibilité dans les neurones.
Mccullough Louise D.
Mcfadden Jill
Ronnett Gabriele V.
Fasgen Llc
Johns Hopkins University
Shapiro Cohen
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