Novel method of progesterone delivery and affect thereof

Details Novel method of progesterone delivery and affect thereof Novel method of progesterone delivery and affect thereof

A - Human Necessities

61

K

A61K 31/57 (2006.01) A61K 9/00 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2171939

The present invention teaches that relatively low levels of serum progesterone, 1 to 6 ng/ml, may be used to prevent endometrial cancer. The vaginal delivery of progesterone using a cross-linked polycarboxylic polymer produces this low serum progesterone level while also providing the full secretory transformation of the endometrium, indicating the efficacy of the progesterone. Such low levels of serum progesterone will decrease the risk of breast cancer experienced by women undergoing hormone replacement therapy ("HRT") and minimize the potential of other undesirable progesterone associated side effects.

La présente invention concerne la possibilité d'administrer des quantités relativement basses de progestérone sérique (de 1 à 6 ng/ml) pour prévenir le cancer de l'endomètre. L'administration de progestérone par voie vaginale en utilisant un polymère polycarboxylique réticulé provoque ce bas niveau de progestérone sérique tout en assurant une complète transformation sécrétoire de l'endomètre, signe de l'efficacité de la progestérone. Ces niveaux bas de progestérone sérique diminueront les risques de cancer du sein rencontré chez les femmes suivant une hormonothérapie substitutive, et réduiront le potentiel des autres effets secondaires indésirables associés à la progestérone.

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