A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/335 (2006.01) A61K 31/47 (2006.01) A61K 31/4745 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61K 49/18 (2006.01) A61K 51/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2492080
The present invention relates to a method of stabilizing a low molecular weight compound in a cationic liposome, wherein said compound has a low solubility in a lipid membrane and/or a low permeability across a lipid membrane. Preferably, the compound is modified in order to increase lipid membrane solubility and/or lipid membrane permeability. After delivery of the cationic liposome to a target site, particularly a target site in an organism, the modification is reversed and the low molecular weight compound may enact its desired activity.
L'invention concerne un procédé pour stabiliser un composé de faible poids moléculaire dans un liposome cationique, ce composé étant peu soluble et/ou présentant une faible pénétration dans une membrane lipidique. Ce composé est modifié de préférence pour augmenter sa solubilité dans une membrane lipidique et/ou la perméabilité d'une membrane lipidique. Le liposome cationique étant fourni à un site cible, notamment un site cible dans un organisme, la modification est inversée et le composé de faible poids moléculaire peut alors développer son activité.
Fichert Thomas
Haas Heinrich
Michaelis Uwe
Peymann Toralf
Schulze Brita
Medigene Ag
Medigene Oncology Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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