C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 67/10 (2006.01) C07C 69/712 (2006.01)
Patent
CA 2690869
The present invention relates to a novel method for synthesizing fenofibrate. This method is essentially characterized in that it comprises reacting, in a solvent system constituted of a mixture of dimethyl sulphoxide and of a C2-C4 alkyl acetate, a metal salt of fenofibric acid with an isopropyl halide. This method can be used on the industrial scale and makes it possible to obtain a fenofibrate having a quality in accordance with the pharmacopeia without the need for purification by recrystallization.
La présente invention concerne un nouveau procédé de synthèse du fénofibrate. Ce procédé est essentiellement carac-térisé en ce qu'il consiste à faire réagir, dans un système solvant constitué d'un mélange de diméthylsulfoxyde et d'un acétate d'alkyle en C2-C4, un sel métallique de l'acide fénofibrique avec un halogénure d'isopropyle. Ce procédé est utilisable à l'échelle industrielle et permet l'obtention d'un fénofibrate de qualité conforme à la pharmacopée sans la nécessité d'une purification par recristallisation.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Synkem
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